AFMR to honor Einstein clinical scientist with Excellent Investigator Award Meredith Hawkins.
‘This is well-deserved acknowledgement for Dr. Hawkins’ stellar track record as a scientific and translational investigator.’ A previous recipient of AFMR’s Junior Physician-Investigator Award, Dr. Hawkins will present an overview of her work at AFMR’s Henry Christian Awards dinner on April 17, 2012. She will after that accept the award at the Translational Science 2012 meeting on April 19, 2012 in Washington DC. ‘I am honored and thankful to get this award,’ said Dr.The prevalence of inhibitor advancement was higher in those whose missense mutations resided on a haplotype encoding H3 or H4 , although the self-confidence interval in this little subsample of 31 patients included the chance of a null impact . Discussion We investigated a potential mechanism underlying the observation that the incidence of element VIII inhibitors in black individuals with hemophilia A is about twice that in whites.9-16 Our previous investigations of nonhemophilic populations 17,18 led us to predict that the causative hemophilic mutations in approximately 27 percent of black patients would be present on background F8 haplotypes encoding either the H3, H4, or H5 wild-type types of factor VIII.30 These haplotypes differ from the H2 and H1 proteins.17,18 H1 and H2 proteins constitute the available recombinant factor VIII items21-24 and are enriched in plasma-derived factor VIII concentrates, since bloodstream donors in the United States are white predominantly.25-28 We discovered that patients with either an H3 or an H4 background haplotype were more likely with an inhibitor than were individuals whose haplotypes were either H1 or H2, a complete result consistent with our previous findings.48 In this preliminary research, we focused only on black individuals to lessen the magnitude of any potential confounding variables because of population stratification over the haplotype comparison groups.49-51 As the sample size was small, we combined patients into two groups, H1+H2 and H3+H4.