Protein C activity elevated from baseline during the first 6 days in both groups; the mean increase was significantly greater in patients in the DrotAA group than in the placebo group on each one of the first 4 study times . Through the first 28 times, a number of serious adverse events were documented in 119 of 833 patients in the DrotAA group versus 96 of 833 individuals in the placebo group . Through the treatment period, non-serious bleeding occasions were more prevalent among patients getting DrotAA than among those getting placebo , as were serious bleeding events , although the latter difference had not been significant.Her husband Mike refers to her as the ‘glue’ that holds the family together and the type of person who is always ready to give of herself rather than actually take from others. They are excellent traits in any wife, but Mike wanted Hope to also pursue her own private goals, which she had thought little about previously. So the couple decided to join a local Gold’s Gym, which is normally where Hope first found out about NPC competitions. An introvert naturally, Hope developed an unexpected curiosity in the scheduled program, but dismissed it quickly, in part because of her busy schedule.